Nutrient Database

5-HTP

amino acid

Approved

General information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.

EveningEmpty stomach

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Overview

Direct precursor to serotonin derived from Griffonia seed.

Interactions

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5-HTP requires B6

B6 (PLP) is the cofactor for the final step: converting 5-HTP to serotonin via AADC (aromatic L-amino acid decarboxylase). 5-HTP without B6 cannot become serotonin.

Research status

Limited research on longevity effects. May support sleep quality and mood regulation, which are associated with healthy aging, but direct longevity benefits are not established.

Top 5 food sources

Griffonia simplicifolia seedsturkeychickenmilkpotatoespumpkin seedssunflower seedscollard greensseaweed
Expert consensus: Moderate

Do not combine with SSRIs or MAOIs due to serotonin syndrome risk.