Betaine (TMG)
other
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Methyl donor and osmolyte. Betaine contributes to normal homocysteine metabolism.
Top 5 food sources
Expert opinions
Dr. David Sinclair
Sinclair takes about 500 to 1000mg TMG (trimethylglycine / betaine) daily to replenish methyl groups consumed when NAD+ precursors (NMN/NR) are cleared via nicotinamide N-methyltransferase (NNMT) to MeNAM. Without TMG, heavy NMN dosing theoretically can raise homocysteine and deplete SAMe. TMG also re-methylates homocysteine to methionine independently of the folate/B12 pathway. He pairs it with methyl-B12, methylfolate and B6.
Recommended dose: 500–1000 mg
Source: Dr. Sinclair Protocol
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Important methyl donor. Often combined with folate and B12.