Nutrient Database

Citicoline (CDP-Choline)

other

Approved

General information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.

Not before sleepFasting safe

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Overview

Compound of cytidine and choline. Precursor for cell membrane phospholipids and for acetylcholine.

Interactions

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Citicoline + DHA

Citicoline provides CDP-choline for phosphatidylcholine synthesis, while DHA is incorporated into these phospholipids.

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Citicoline + tyrosine as precursors

Citicoline provides choline for acetylcholine synthesis, while L-tyrosine is the direct precursor for dopamine.

Research status

Brain phospholipid synthesis declines with age. Citicoline has been studied in clinical trials with older adults.

Expert consensus: Strong

Typical dose 250 to 500 mg.