Nutrient Database

Lion's Mane

herbal

Approved

General information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.

Not before sleepFasting safe

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Overview

Edible mushroom of the genus Hericium, taken as an extract.

Interactions

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Lion's Mane + B12

Lion's mane contains hericenones and erinacines, which are studied for their effect on NGF (nerve growth factor) production. Vitamin B12 contributes to normal functioning of the nervous system.

Research status

Studied for its effect on nerve growth factor (NGF) synthesis.

Expert opinions

Dr. Andrew Huberman

Huberman has discussed Lion's Mane (Hericium erinaceus) at 500 to 1000 mg/day of a dual extract (hot water plus ethanol) standardized to hericenones and erinacines. He notes emerging anecdotal reports of persistent sexual side effects in some users, so he suggests cycling it rather than taking it daily for life. Best taken with fats.

Source: Huberman Lab

Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.

Expert consensus: Moderate

Dual extract (water + alcohol) preferred for full spectrum of compounds.