Spermidine
other
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Polyamine found in wheat germ and aged cheese.
Interactions
Spermidine and vitamin D3 are both studied in connection with autophagy signaling: spermidine via inhibition of EP300 acetyltransferase, vitamin D3 via AMPK and mTOR.
Research status
Studied for its role in autophagy, the cellular recycling process.
Top 5 food sources
Expert opinions
Bryan Johnson Blueprint
Johnson takes about 1 mg spermidine trihydrochloride daily in Blueprint (wheat-germ-derived). Taken with breakfast. Blueprint monitors LC3-II proxies and inflammatory panels.
Recommended dose: 1–2 mg
Source: Blueprint Protocol
Dr. David Sinclair
Sinclair has cited data on dietary spermidine intake from the Bruneck cohort (Kiechl 2018). He takes spermidine (wheat-germ-derived, typically 1 to 5 mg) alongside periodic prolonged fasting.
Recommended dose: 1 mg
Source: Dr. Sinclair Protocol
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Human data are mainly epidemiological.