Sulforaphane
antioxidant
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Isothiocyanate from cruciferous vegetables that activates the Nrf2 pathway.
Interactions
Vitamin C protects sulforaphane from oxidative degradation and supports the Nrf2 antioxidant response pathway that sulforaphane activates, enhancing the overall cellular antioxidant defense.
Research status
Studied in preclinical models.
Top 5 food sources
Expert opinions
Dr. Rhonda Patrick
Sulforaphane is Dr. Patrick's signature recommendation. She grows 3-day-old broccoli sprouts at home because they contain about 50 to 100 times more glucoraphanin than mature broccoli. She pairs them with a pinch of moringa seed powder (rich in myrosinase) or a brief heat shock (70 °C for 10 min) to convert glucoraphanin to active sulforaphane. She cites work by Fahey and Talalay (Johns Hopkins) on sulforaphane and the Nrf2 pathway. Target: the equivalent of 20 to 40 mg sulforaphane daily.
Recommended dose: ~40 mg (from sprouts)
Source: FoundMyFitness
Dr. David Sinclair
Johnson includes about 10 mg stabilized sulforaphane daily in Blueprint. He favors standardized glucoraphanin and myrosinase capsules (TrueBroc) over unstabilized sprout powders, since sulforaphane degrades rapidly at ambient temperature. Taken with the morning meal. The oxidative markers MDA, GGT and 8-OHdG are tracked quarterly.
Source: Dr. Sinclair Protocol
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Best from broccoli sprouts or stabilized supplements. Myrosinase needed for activation.