Nutrient Database

Urolithin A

other

Approved

General information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.

Fasting safe

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Overview

Postbiotic compound studied for its role in mitophagy, the process of recycling damaged mitochondria.

Interactions

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Urolithin A + CoQ10 for mitophagy

Urolithin A acts on mitophagy (selective removal of damaged mitochondria) via PINK1/Parkin signaling. CoQ10 is an electron carrier in the respiratory chain of the remaining mitochondria.

Expert opinions

Dr. David Sinclair

Sinclair highlights urolithin A (UA) in connection with mitophagy. Only about 40 % of adults harbor the gut flora needed to convert dietary ellagitannins to UA. Direct supplementation (Mitopure, 500 mg) does not depend on this conversion. He cites studies by Andreux (2019) and Liu (2022, Cell Reports Medicine) in older adults.

Recommended dose: 500 mg

Source: Dr. Sinclair Protocol

Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.

Expert consensus: Moderate

Timeline (Mitopure) is the most studied brand.