Vitamin K2
vitamin
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Fat-soluble vitamin, often combined with vitamin D3. Vitamin K contributes to the maintenance of normal bones. Vitamin K contributes to normal blood clotting.
Interactions
Vitamin D3 upregulates the production of K2-dependent proteins (osteocalcin, MGP). Without adequate D3, K2 has fewer target proteins to activate.
K2 carboxylates osteocalcin and matrix GLA protein, two proteins that bind calcium. Vitamin K contributes to the maintenance of normal bones.
Research status
The MK-7 form activates matrix GLA protein.
Top 5 food sources
Expert opinions
Bryan Johnson Blueprint
Johnson takes 600 µg MK-7 daily, well above typical 100 µg protocols, paired with 2,000 IU D3. Blueprint tracks coronary artery calcium (CAC) score as a biomarker. The high MK-7 dose remains tolerated because K2's half-life stays within safe range even with daily accumulation. Never combined with warfarin or other vitamin K antagonists.
Recommended dose: 100 mcg
Source: Blueprint Protocol
Dr. Strunz
Strunz prescribes 100 to 200 µg MK-7 daily as an inseparable partner to vitamin D3. Vitamin K contributes to the maintenance of normal bones. MK-7 is preferred over MK-4 for its half-life of about 72 h versus about 1.5 h, giving steadier tissue saturation. Pairs well with magnesium and D3. Bleeding risk is negligible at these doses except under warfarin therapy.
Recommended dose: 100–200 mcg
Source: Dr. Strunz
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Broad agreement on K2+D3 pairing. No established UL — considered very safe.