Nutrient Database

Berberine

herbal

Approved

General information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.

Fasting safe

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Overview

Plant alkaloid used as a dietary supplement.

Interactions

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Berberine + ALA

Both activate AMPK (the cellular energy sensor) through different mechanisms: berberine inhibits mitochondrial complex I, ALA activates AMPK via CaMKKβ.

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Berberine and chromium

Berberine activates the enzyme AMPK. Chromium contributes to the maintenance of normal blood glucose levels.

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Berberine depletes B1

Berberine inhibits thiamine (B1) transport proteins in the intestinal epithelium, potentially causing thiamine depletion with chronic use. Consider supplementing B1 alongside berberine.

Research status

Activates the enzyme AMPK. Studied in animal models and in humans.

Expert consensus: Strong

Can affect the gut microbiome. Take with meals.

Berberine — Stackwell