Fisetin
other
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Flavonoid found in strawberries.
Interactions
Fisetin and quercetin are flavonoids that are studied for their effects on senescent cells. They act on different anti-apoptotic pathways (BCL-2 family).
Research status
Studied as a potential senolytic in animal models. Human trials are underway.
Top 5 food sources
Expert opinions
Current Research
Fisetin is a flavonoid from strawberries and apples that has been studied in aged mice (Yousefzadeh 2018, EBioMedicine). Human trials (Mayo Clinic NCT03675724, NCT03430037) are testing 20mg/kg/day for 2 days monthly. Because oral bioavailability of crystalline fisetin is about 10%, novel sustained formulations (liposomal, Novusetin) or coadministration with fat are required. Used as a pulse, not a daily supplement. Robust human data are lacking.
Recommended dose: 100–500 mg (periodic)
Source: Current Research
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Human clinical trials still early-stage.