NMN (Nicotinamide Mononucleotide)
antioxidant
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Direct NAD+ precursor, related to NR.
Interactions
NMN rapidly boosts NAD+ levels as a direct precursor, while resveratrol allosterically activates SIRT1. The combination provides both increased substrate and enzyme activation for maximal sirtuin activity.
NMN raises NAD+ levels, the substrate of the enzyme SIRT1. Resveratrol is studied as an activator of SIRT1.
Research status
Studied in mice. Large human trials ongoing.
Top 5 food sources
Expert opinions
Dr. David Sinclair
NMN is the second pillar of Sinclair's sirtuin protocol. He takes 1 g sublingually every morning on an empty stomach. NMN is the direct precursor one step before NAD+ (via NMNAT enzymes). Sublingual dosing is meant to bypass CD38-mediated degradation in the gut. He combines NMN with 1 g trans-resveratrol.
Recommended dose: 1000 mg
Source: Dr. Sinclair Protocol
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Data mainly from animal studies. Human long-term data still limited. NR vs NMN debate ongoing.