NR (Nicotinamide Riboside)
antioxidant
ApprovedGeneral information about nutrients. No diagnosis, no medical advice. If you take medication, are pregnant or have a medical condition, talk to your doctor before taking supplements.
Overview
Form of vitamin B3 and a precursor to NAD+.
Interactions
Nicotinamide riboside elevates NAD+ via the NRK salvage pathway, while resveratrol activates SIRT1 that depends on NAD+ as a co-substrate. Together they enhance sirtuin-mediated cellular maintenance.
Nicotinamide riboside raises NAD+ levels as a substrate, while pterostilbene activates SIRT1 and SIRT3 sirtuins that consume NAD+.
Research status
Studied in aged mice. Human trials show increased NAD+ levels, effects on aging are still under investigation.
Top 5 food sources
Expert opinions
Bryan Johnson Blueprint
Johnson includes nicotinamide riboside (NR, Niagen brand) in Blueprint at about 375 to 500 mg daily as his preferred NAD+ precursor after evaluating both NR and NMN data. NR bypasses the rate-limiting NAMPT step and requires only the NRK1/2 salvage step. Taken with breakfast. Blueprint tracks the NAD+/NADH ratio and PBMC NAD+ via LC-MS quarterly.
Recommended dose: 300 mg
Source: Blueprint Protocol
Expert profiles summarise publicly available statements. The named people do not cooperate with Stackwell and have not authorised these summaries. Not medical advice.
Raises NAD+ levels. Long-term effects still under investigation.